NFL Predictions Kansas City Chiefs vs. San Francisco 49ers Over/Under: 48.5 Odds: Chiefs -3, 49ers +3 Time: 4:25 PM ET We keep on trucking forward when it comes to these predictions for the week. This time, we are going to be covering the matchup between the Kansas City Chiefs and the San Francisco 49ers. Both of these teams are entering this matchup following tough losses, but there’s opportunity for one of them to get a nice bounce back win. How Last Week Went The Chiefs are coming into this game after losing to the Buffalo Bills in a Divisional Round rematch. The Chiefs had the ball with one minute left to try and win the game at the end of regulation, but Patrick Mahomes threw a costly interception to seal the game. It was actually the second interception for Mahomes here, twice as many picks this week as he’s had all season long. He was sort of forced to air it out constantly as the run game never really got going. Well, they didn’t try it enough for it to do so. Clyde Edwards-Helaire had nine rushes for 33 yards, Isiah Pacheco had two for nine and Jerick McKinnon had two for one. On the defensive end, the Chiefs were playing without a handful of their starters in the secondary. They held up well, but help could be needed sooner rather than later. Now we flip over to the 49ers. They just got manhandled by the Atlanta Falcons, never being really competitive. Jimmy Garoppolo played decently, throwing for 296 yards, two touchdowns and two interceptions. However, the run game didn’t get anything going, forcing so much pressure on Jimmy G and a depleted 49ers defense. Jeff Wilson had seven rushes for 25 yards, Deebo Samuel had two for 11 and Tevin Coleman had four for three. Just like the Chiefs, the run game was nowhere to be found. As for the defense, half of their starters were out of action. One report stated that the team was missing a whopping SEVEN defensive starters for that game. Mind you, there’s only 11 starters on a defense. So, they didn’t have about 70 percent of their defensive talent available. They will certainly need it if they want to stop the Chiefs and Mahomes. NFL Picks Today In my opinion, this game doesn’t seem very hard when it comes to making predictions. The Chiefs very rarely lose two games in a row with Mahomes and Andy Reid both there for them. Plus, the 49ers are missing too many defensive starters due to injuries for them to be able to keep up. If Kansas City gets an early lead, then Garoppolo and company will have to lean on the passing game. Something they’ve not done well with so far this season. Roll with the Chiefs with confidence. Then we talk about the total which is set for this game. It’s set at 48.5 points and that looks like a total that could reach the over. The Chiefs could pretty quickly light up the 49ers defense if they don’t get some guys back from injury. That offensive explosion could force the 49ers to air it out themselves. It could turn the game into a shootout if both offenses get hot. Final Pick: Chiefs -3 Over/Under Choice: Over 48.5 If you’re looking for more content, click here!