Soldier Field will host a first-ever meeting between Chicago Fire and MLS newcomers San Diego FC this Sunday, in what promises to be a high-stakes matchup. Despite being a new franchise, San Diego have taken the league by storm, while Chicago continue to fall short of expectations in 2025. Need help with your MLS picks? Stick with MatchPlug for smart, data-backed predictions. Betting Preview for Chicago Fire vs San Diego FC Betting On Chicago Fire The Fire have struggled in all areas this season and are still recovering from back-to-back losses. They’re also one of the worst home sides in MLS this year, with just two home wins. Injury concerns are mounting too, with seven players currently out. Belgian striker Hugo Cuypers has returned but hasn’t found top form, scoring just once in five games since his return. Betting On San Diego FC San Diego FC continue to impress in their debut season. Even after a narrow 4-3 loss to Houston, their attack is firing. Striker Milan Iloski is in brilliant form, including four goals against Vancouver on July 25. Midfield creator Onni Valakari is also delivering, with a goal and two assists in his last outing. San Diego are set to welcome back key players like Lozano and Andres Reyes, while Iloski and Dreyer will likely lead the front line again. MatchPlug Prediction for Chicago Fire vs San Diego FC Chicago’s home form and injury list make them hard to trust. While Cuypers is back, the Fire haven’t shown enough attacking consistency or defensive stability. In contrast, San Diego FC are scoring freely and come in with a more complete squad and stronger momentum. Expect San Diego to dominate offensively and take advantage of a struggling Fire team. Final Prediction: San Diego FC Moneyline

St. Louis City SC welcome Portland Timbers to Energizer Park this Sunday in a battle between two Western Conference teams in very different places. While St. Louis sit 14th and are struggling for form, Portland are up in fourth and pushing to close the gap on the top three. Read on for MatchPlug’s betting preview and prediction for this MLS clash. Betting Preview for St. Louis City SC vs Portland Timbers Betting On St. Louis City SC St. Louis have just 15 points this season and are stuck near the bottom of the Western Conference. They’ve lost four of their last five league games, with their only decent result coming in a 3-3 draw with LA Galaxy. While they’ve been slightly better at home, going W2, D3, L2 in their last seven at Energizer Park, it’s far from convincing. Betting On Portland Timbers Portland are in 4th place with 33 points and recently beat New England Revolution 2-1, returning to winning ways after two tough games. They’ve won three of their last five league fixtures, showing solid overall form. However, their away record is a concern — they haven’t scored in any of their last four road games across all competitions, picking up just one point in that stretch. MatchPlug Prediction for St. Louis City SC vs Portland Timbers Portland may not be at their best on the road, but they’re facing a St. Louis team in a rough patch. This could be the ideal time for the Timbers to break their away scoring drought and grab all three points. The last time these two met, Portland edged a 2-1 win, and a similar result could be on the cards. Final Prediction: Over 2.5 Goals

Los Angeles FC welcome FC Dallas to BMO Stadium this Saturday in a key Western Conference matchup in the 2025 MLS season. Read our preview for the LAFC vs FC Dallas match. Both teams are chasing consistency, but only one appears ready to turn the corner. Read MatchPlug’s preview for the latest insight into this clash. Betting Preview for LAFC vs FC Dallas Betting On LAFC LAFC are 6th in the Western Conference with 29 points from 18 matches. They returned to winning ways midweek with a convincing 3-0 victory over Colorado Rapids, snapping a four-game winless streak. New signing Javairo Dilrosunopened his goal account in that match, adding another dimension to LAFC’s attack. At home, LAFC have been tough to beat, with only one loss in their last seven home league matches. They’ll look to build momentum with back-to-back wins. Betting On FC Dallas Dallas are 13th in the West with just 21 points and are currently on a three-game losing streak. Their most recent outing saw them fall 2-1 at home to Minnesota United, despite a late goal from Logan Farrington, who finally ended his 17-game goal drought. Dallas have struggled both home and away, and with just one win in their last ten matches across all competitions, the visitors are desperate for a turnaround. MatchPlug Prediction for LAFC vs FC Dallas LAFC have rediscovered some form and will be confident playing at home. Dallas, meanwhile, look out of rhythm and have a poor away record to match. Expect LAFC to dominate possession, create more chances, and take all three points. Final Prediction: LAFC Moneyline

Subaru Park will host a key Eastern Conference clash this Sunday as Philadelphia Union take on New York Red Bulls. Here’s our preview of the Philadelphia Union vs New York Red Bulls. Both teams are pushing for higher spots in the standings, making this an important fixture for their playoff hopes. Read MatchPlug’s betting preview below before placing your bets on this MLS encounter. Betting Preview for Philadelphia Union vs New York Red Bulls Betting On Philadelphia Union Philadelphia Union are currently 3rd in the Eastern Conference. Although they lost narrowly 1-0 to Nashville SC in their last match, they have shown strong form overall this season. With home support and a solid attacking lineup, Union will aim to return to winning ways at Subaru Park, where they’ve been tough to beat. Betting On New York Red Bulls New York Red Bulls are 8th in the East and have struggled to find consistency. They drew 1-1 with San Jose Earthquakes in their last outing and will need a much sharper performance to challenge Philadelphia away from home. Their defense will be tested, and they’ll need to be more clinical in the final third. MatchPlug Prediction for Philadelphia Union vs New York Red Bulls Philadelphia have looked like one of the more balanced sides this season and have been reliable at home. The Red Bulls have struggled to turn chances into goals and may not have enough firepower to get past a well-drilled Union defense. Final Prediction: Philadelphia Union Over/Under