Wednesday’s MLB action rolls into Oriole Park at Camden Yards as the St. Louis Cardinals and Baltimore Orioles wrap up their three-game interleague series. Read our preview for the Cardinals vs Orioles.
The Orioles took the opener and aim to win the set in front of their home crowd. Read on for our prediction and betting insights.
Betting Preview For Cardinals vs Orioles
- Venue: Oriole Park at Camden Yards, Baltimore, MD
- Date: Wednesday, May 28, 2025
- Time: 6:35 PM ET
- Teams: Cardinals vs Orioles
- Odds provided by 1XBet
Betting On St. Louis Cardinals
The Cardinals saw their three-game winning streak snapped with a quiet night at the plate on Monday, managing just four hits and committing two key defensive errors. St. Louis is still riding a strong May and remains in contention in the NL Central, just behind the Cubs.
Miles Mikolas gets the nod, bringing a 4-2 record and 3.51 ERA into his 11th start of the season. He’s been in great form recently, giving up just two earned runs in his last 17.1 innings. While the Cardinals’ offense has been top-10 overall, it has slumped hard against left-handed pitching, hitting just .556 OPS over the past 10 days.
Betting On Baltimore Orioles
The Orioles may be having a disappointing season overall, but they’ve picked up momentum with a three-game win streak. A key swing by Dylan Carlson powered them past St. Louis in the opener, and they’ll aim to continue riding that wave.
Cade Povich starts for Baltimore, carrying a 1-3 record and 4.86 ERA. While his season stats are mediocre, he’s looked sharper lately, allowing only three earned runs over his last 10.2 innings. The Cardinals have never faced Povich, and Baltimore’s offense has performed well against righties recently, logging a .734 OPS over the last 10 days.
MatchPlug Prediction For Cardinals vs Orioles
The Orioles have the edge here thanks to their current offensive form against right-handers and the Cardinals’ struggles against southpaws. Cade Povich has shown signs of improvement and faces a St. Louis lineup that hasn’t figured out lefties lately. With Baltimore showing fight and home-field advantage, we’re backing the O’s to win the rubber match.
Final Prediction: Baltimore Orioles Moneyline (-115)
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