The San Francisco Giants travel to face the struggling Chicago White Sox in a Friday night interleague matchup at Guaranteed Rate Field. Read our full preview for the San Francisco Giants vs Chicago White Sox game.Both teams are coming off mixed results, but the Giants are eager to rebound from a poor run in late June, while the White Sox look to build on a rare win. The game is scheduled for 12:40 AM (Saturday morning) Nigerian time.
Matchplug is your best plug for up-to-date betting picks and analysis.With both sides desperate to build momentum, this contest offers an interesting betting opportunity.
Betting Preview for San Francisco Giants vs Chicago White Sox
- Venue: Guaranteed Rate Field, Chicago
- Date: Friday, June 28, 2025
- Time: 12:40 AM WAT (7:40 PM ET)
- Teams: San Francisco Giants vs Chicago White Sox
Odds as provided by 1XBet
Betting on the San Francisco Giants
- 1XBet Spread: -1.5
- 1XBet Moneyline: -165
- 1XBet Over/Under: Over 8.5
San Francisco has dropped seven of its last 10 games, including back-to-back losses to Miami. Their offense has been sluggish lately, posting a poor .211 average over that span.
However, right-hander Landen Roupp will start on the mound after tossing six shutout innings in a win over Boston last weekend. Roupp has been solid in interleague play, boasting a 1.64 ERA across seven such starts. Though the Giants haven’t hit right-handed pitchers particularly well of late, their more powerful lineup could prove the difference against a shaky Chicago rotation.
Betting on the Chicago White Sox
- 1XBet Spread: +1.5
- 1XBet Moneyline: +140
- 1XBet Over/Under: Under 8.5
The White Sox have only won three of their last 14 games, despite a recent win over Arizona led by Lenyn Sosa’s two home runs. Offensively, they’ve been quiet, slashing just .214/.277/.348 in that stretch.
Aaron Civale is set to pitch for Chicago, and while he owns a solid career record (2-0, 2.01 ERA) against the Giants, he struggled in his last outing, allowing five earned runs in seven innings. The White Sox bullpen has been decent, but their lack of offense against right-handers makes it difficult to trust them here.
MatchPlug Prediction for San Francisco Giants vs Chicago White Sox
While Aaron Civale’s past success against the Giants can’t be ignored, his recent form has been poor. Landen Roupp, on the other hand, is trending in the right direction and should have the edge against a White Sox team that’s struggling to hit right-handers.
Our prediction for Friday’s clash is a Giants win by at least two runs, as San Francisco’s superior pitching and batting depth should be enough to overpower a lackluster Chicago side.
Final Prediction: San Francisco Giants -1.5
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