Cagliari welcomed Inter Milan to the Unipol Domus on Sunday in matchday five of the 2025-26 Serie A season. Read our preview for the Cagliari vs Inter Milan match. Both teams are seeking to gain momentum, with Inter eager to climb the table after an inconsistent start. MatchPlug provides the preview, betting tips, and prediction for this clash.
Betting Preview for Cagliari vs Inter Milan
- Venue: Unipol Domus, Cagliari
- Date: Sunday, September 28, 2025
- Kick-off: 20:45 CET
- Teams: Cagliari vs Inter Milan
- Odds provided by 1XBet
Betting on Cagliari
- Spread: +0.75
- Moneyline: 4.60
- O/U: Over 2.5
Cagliari have enjoyed a strong run recently, taking six points from their last two Serie A games and then crushing Frosinone 4-1 in the Coppa Italia midweek. Andrea Belotti’s brace helped seal a 2-1 comeback victory at Lecce last weekend.
However, history isn’t on their side — Cagliari are winless in their last 11 league meetings with Inter and will need another inspired performance to halt that streak.
Betting on Inter Milan
- Spread: –0.75
- Moneyline: 1.72
- O/U: Over 2.5
Inter Milan have had a mixed start, recording two wins and two defeats in their opening four league fixtures. Their midweek 2-0 away win at Ajax in the Champions League showed they can still deliver at the highest level.
The Nerazzurri have dominated this matchup, winning 14 of the last 15 Serie A meetings, including eight of nine away games. Simone Inzaghi’s men will look to extend that dominance to kick-start their domestic campaign.
MatchPlug Prediction for Cagliari vs Inter Milan
Cagliari’s recent form gives them confidence, but Inter’s historical supremacy in this fixture is hard to ignore. Both sides have looked shaky at the back, and goals at both ends feel likely.
Final Prediction: Inter Milan to Win
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