What started as a feud between Jose Mourinho and Paul Pogba is beginning to have an effect on the team spirit at Manchester United, and a bad result in this game could spell the end for the Portuguese manager.
The Red Devils were beaten 3-1 by West Ham at the weekend to continue a bad run of results that has now become their worst start to the league season since 1989.
That loss was also the 3rd time the Red Devils have failed to win a game in their last three games and their second defeat in as many games.
So the stakes are high for Jose Mourinho ahead of the visit of this Valencia side who are beginning to gel after a summer of major additions.
Valencia beat Real Sociedad to record their first win of the season at the weekend, but they have not been losing much either. As a matter of fact, Los Che have only lost twice this season as they have 5 draws from 8 games so far.
They lost their first Champions League game at home to Juventus, while Manchester United won their first game away at Young Boys.
However, this match would be tougher for the Red Devils as Valencia have only conceded 8 times in as many games this season even though they have also scored just 5 times.