Interim manager for the Red Devils Ruud van Nistelrooy will oversee his first Premier League match today. They will host Manchester United VS Chelsea in a mega Premier League showdown. Use MatchPlug to get the Football Prediction for today, picks, odds, and analysis for Manchester United VS Chelsea. We are a Winning Prediction Site to get Premier League previews. Predictions and Betting Preview For Manchester United VS Chelsea Odds provided by 1XBet. Betting On Manchester United This will be the first Manchester United EPL match since they sacked Erik ten Hag early this week. Acting manager Ruud van Nistelrooy secured a massive 5-2 victory in his first match heading the club against Leicester in the Carabao Cup. Van Nistelrooy gears up for his first Premier League match as interim with most of his squad absent. Mason Mount, Kobbie Mainoo, and Harry Maguire have missed recent games, joining other absentees like Tyrell Malacia, Leny Yoro, and Luke Shaw. Christian Eriksen also missed the midweek fixture against Leicester and Antony is out with an ankle sprain. Betting On Chelsea Meanwhile, Chelsea complemented their 2-1 victory over Newcastle in the EPL, with a 2-0 loss against the Magpies in the Carabao Cup on Wednesday night. But, Enzo Maresca’s squad have been impressive this year and lost just once away in the League under his guidance so far. The Blues are expected to make some massive changes to the squad that lost to Newcastle. All of Enzo’s best players are expected to resume their duties this weekend. However, Jadon Sancho, who was absent during the defeat by the Magpies due to an illness, will not play against Manchester. MatchPlug Prediction For Manchester United VS Chelsea Manchester United would have been inspired by their midweek score and maybe Van Nistelrooy too is in the mood to win some matches. But, Chelsea is at full power now and a dangerous opponent to anger. Final Prediction: Chelsea Moneyline.