Manchester United will look to continue their recent fine run of form after two wins from two games and they face an Omonia side that gave them some trouble in the reverse fixture.
The Red Devils won the game 3-2 and that score clearly shows the visitors did not make life easy for them on different levels.
United also beat Everton 2-1 in their last Premier League game to show they have recovered well from the 6-3 loss to Manchester City.
This game is another chance for them to show they are a top club under Erik Ten Hag and it will hand Cristiano Ronaldo a chance to add to his 700 career club goals.
Omonia almost pulled off a win in the first leg, but they ultimately lost. They know this reverse fixture would be tougher, but we expect them to still give a good fight for the points.
They lost to AEL Limassol at the weekend, so they need a performance in this game to give themselves a confidence boost.
The best bet prediction for this game is over 2.5 goals. For similar predictions, click here.
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