Liverpool would look to recover from their 2-2 draw against Brighton at the weekend to complete the work they started at the Wanda Metropolitano.
The Reds beat Atleti 3-2 in the reverse of this fixture, and the crowd at Anfield would urge them on to beat the Spaniards again.
Atleti drew their next two games after the defeat at the hands of Liverpool, but they returned to winning ways at the weekend when they beat Real Betis 3-0.
They know facing Liverpool is a different ball game, and the Reds would have vengeance on their minds.
Atleti eliminated Liverpool from the Champions League in 2020 and they did that in front of the Anfield crowd.
Liverpool would be frustrated that Brighton stopped their winning run at the weekend, but this game gives them the chance to return to winning ways.
Liverpool may have lost in extra time the last time both clubs, but the Red have a good head-to-head record in this fixture.
They have won the last two fixtures between both clubs and they have three wins and just one loss from their last five head to heads.