Fresh from securing a World Cup place via a 1-0 win against Ukraine, Wales will look to add more wins to their ranks against this in-form Netherlands side.
The visitors have just beaten Belgium 4-1 and will be full of confidence ahead of this game, but Wales are a team you simply cannot underestimate.
They have been building a strong team in recent years and qualifying for the World Cup is a testament to what they can acheive.
But under Luis Van Gaal, The Netherlands have become one of the strongest countries in Europe and their win against Belgium showed the remain a strong team.
They are unbeaten in over 10 matches and they have won seven of their last 10 matches and will be keen to add this one to the list.
They also have a solid head to head record in this fixture with five wins from as many games.